In 1944, Erwin Schrodinger proposed that there may be a Law, other than Thermodynamics, to regulate processes in Living Cells - Cubic Hydration Patterning may be that Law.
Cubic hydration on lipid surfaces of natural polypeptides may, not only provide direction for the formation of proteins, but the energy to move them from randomness toward order.
The Order/Disorder properties of water appear to play a critical role in the catalytic hydrolyses of aromatic peptides from the ends of polypeptide chains. Here is a graphic interpretation of that role.
Ribonuclease A is presented below as an example of how surface water, by repetitively forming picosecond ice-like linear elements of hydration on lipid surfaces of its polypeptide, not only directs and drives its wrapping and assembly into its unique protein structure, but its enzymatic activity as well.
The article describes how surface hydration in transient linear elements most likely assists in directing and driving the folding and assembly of the polypeptide of alpha chymotrypsin into the active enzyme and how it assists in catalytic cleavage of polypeptides.
The roles of linear hydration and cubic patterning in regulating the structure and binding process between the omicron viral spike and ACE2 enzyme are presented in the attached article.